DAB2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-14925-20uL | 20uL | £125.00 |
Quantity:
| E-AB-14925-60uL | 60uL | £172.00 |
Quantity:
| E-AB-14925-120uL | 120uL | £237.00 |
Quantity:
| E-AB-14925-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
DAB2
Background:
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
82kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Recombinant protein of human DAB2
Purification method:
Affinity purification
Target Synonym:
DAB 2;Dab;mitogen-responsive phosphoprotein;homolog 2 (Drosophila);DAB2;Differentially expressed in ovarian cancer 2;Differentially expressed protein 2;Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein);Disabled homolog 2;Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila);Disabled homolog 2 mitogen responsive phosphoprotein;Disabled;Drosophila;homolog of;2;DOC 2;DOC2;FLJ26626;Mitogen responsive phosphoprotein
UNIProt ID:
P98082