CRK Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-14896-20uL | 20uL | £125.00 |
Quantity:
| E-AB-14896-60uL | 60uL | £172.00 |
Quantity:
| E-AB-14896-120uL | 120uL | £237.00 |
Quantity:
| E-AB-14896-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
CRK
Background:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human CRK
Purification method:
Affinity purification
Target Synonym:
Adapter molecule crk;Avian sarcoma virus CT10 (v crk) oncogene homolog;CRK;CRK isoform 2;CRK isoform II;CRK;CRKII;FLJ38130;OTTHUMP00000115366;OTTHUMP00000198330;p38;Proto oncogene C crk;Proto-oncogene C-crk;v crk avian sarcoma virus CT10 oncogene homolog;v crk sarcoma virus CT10 oncogene homolog;v crk sarcoma virus CT10 oncogene homolog (avian)
UNIProt ID:
P46108