Cleaved-PARP1 (D214) Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-30080-20uL | 20uL | £125.00 |
Quantity:
| E-AB-30080-60uL | 60uL | £172.00 |
Quantity:
| E-AB-30080-120uL | 120uL | £237.00 |
Quantity:
| E-AB-30080-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
Cleaved-PARP1 (D214)
Background:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
113kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Immunogen:
Synthesized peptide derived from the Internal region of human PARP-1
ObservedMW:
24kDa
Purification method:
Affinity purification
Target Synonym:
ADP-ribosyltransferase diphtheria toxin-like 1;ADPRT 1;ADPRT;ADPRT1;APOPAIN;ARTD1;NAD(+) ADP-ribosyltransferase 1;PARP;PARP-1;PARP1;PARP1;Poly [ADP-ribose] polymerase 1;Poly ADP ribose polymerase 1;Poly[ADP-ribose] synthase 1;PPOL;SCA1
UNIProt ID:
P09874
References
- https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.23749
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485694/