CHRNA2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-16340-20uL | 20uL | £125.00 |
Quantity:
| E-AB-16340-60uL | 60uL | £172.00 |
Quantity:
| E-AB-16340-120uL | 120uL | £237.00 |
Quantity:
| E-AB-16340-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
CHRNA2
Background:
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
60kDa
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:25-1:100
Immunogen:
Synthetic peptide of human CHRNA2
Purification method:
Affinity purification
Target Synonym:
ACHA2;AChR;Cholinergic receptor nicotinic alpha 2;Chrna2;Neuronal acetylcholine receptor protein subunit alpha 2;Neuronal acetylcholine receptor subunit alpha-2
UNIProt ID:
Q15822