CHRDL2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-13148-20uL | 20uL | £125.00 |
Quantity:
| E-AB-13148-60uL | 60uL | £172.00 |
Quantity:
| E-AB-13148-120uL | 120uL | £237.00 |
Quantity:
| E-AB-13148-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
CHRDL2
Background:
CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
48kDa
Concentration:
0.3 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Synthetic peptide of human CHRDL2
Purification method:
Affinity purification
Target Synonym:
BNF-1;BNF1;Breast tumor novel factor 1;CHL2;chordin like 2;Chordin like protein 2 precursor;Chordin related protein 2;Chordin-like protein 2;Chordin-related protein 2;Chrdl2;CRDL2;DKFZp586N2124;FKSG37
UNIProt ID:
Q6WN34