CASP3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-13815-20uL | 20uL | £125.00 |
Quantity:
| E-AB-13815-60uL | 60uL | £172.00 |
Quantity:
| E-AB-13815-120uL | 120uL | £237.00 |
Quantity:
| E-AB-13815-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
CASP3
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
32kDa
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000, IHC 1:50-1:200
Immunogen:
Recombinant protein of human CASP3
Purification method:
Affinity purification
Target Synonym:
A830040C14Rik;Apopain;CASP-3;CASP3;CASP3;Casp3a;Caspase 3;Caspase 3;apoptosis-related cysteine peptidase;Caspase 3;apoptosis-related cysteine protease;Caspase 3;apoptosis-related cysteine protease a;Caspase-3 subunit p12;CC3;CPP-32;CPP32;CPP32B;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;Protein Yama;SCA 1;SCA-1;SREBP cleavage activity 1;Yama
UNIProt ID:
P42574
References
- https://www.sciencedirect.com/science/article/pii/S1382668922001739
- https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-022-00747-3
- https://europepmc.org/article/pmc/pmc8333701?javascript_support=no
- https://www.sciencedirect.com/science/article/pii/S0300483X18303937
- https://link.springer.com/article/10.1007/s12011-018-1535-3
- https://www.sciencedirect.com/science/article/pii/S2666027X22000093