BCL-x Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-30640-20uL | 20uL | £125.00 |
Quantity:
| E-AB-30640-60uL | 60uL | £172.00 |
Quantity:
| E-AB-30640-120uL | 120uL | £237.00 |
Quantity:
| E-AB-30640-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
Bcl-x
Background:
Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
26kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Immunogen:
Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47.
ObservedMW:
30kDa
Purification method:
Affinity purification
Target Synonym:
Apoptosis regulator Bcl X;Apoptosis regulator Bcl-X;Apoptosis regulator BclX;B cell lymphoma 2 like;B2CL1;Bcl 2 like 1 protein;Bcl X;Bcl xL;BCL XL/S;Bcl xS;Bcl-2-like protein 1;Bcl2 Like 1;Bcl2 related gene;Bcl2-L-1;BCL2L;Bcl2l1;BCLX;BclXL;BclXs;DKFZp781P2092;PPP1R52;Protein phosphatase 1 regulatory subunit 52
UNIProt ID:
Q07817