APAF1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-12215-20uL | 20uL | £125.00 |
Quantity:
| E-AB-12215-60uL | 60uL | £172.00 |
Quantity:
| E-AB-12215-120uL | 120uL | £237.00 |
Quantity:
| E-AB-12215-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
APAF1
Background:
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
142kDa
Concentration:
0.7 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human APAF1
Purification method:
Affinity purification
Target Synonym:
APAF 1;Apaf-1;APAF;Apaf1;Apoptotic peptidase activating factor 1;Apoptotic protease activating factor 1;Apoptotic protease activating factor;Apoptotic protease-activating factor 1;CED 4;CED4;KIAA0413
UNIProt ID:
O14727