AIM2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-10974-20uL | 20uL | £125.00 |
Quantity:
| E-AB-10974-60uL | 60uL | £172.00 |
Quantity:
| E-AB-10974-120uL | 120uL | £237.00 |
Quantity:
| E-AB-10974-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
AIM2
Background:
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-, AIM2 is thought to act as a tumor suppressor by repressing NFB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.8 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human AIM2
Purification method:
Affinity purification
Target Synonym:
Absent in melanoma 2;AIM 2;Aim2;AIM2;Interferon-inducible protein AIM2;OTTHUMP00000035296;PYHIN4
UNIProt ID:
O14862