ACO1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-12938-20uL | 20uL | £125.00 |
Quantity:
| E-AB-12938-60uL | 60uL | £172.00 |
Quantity:
| E-AB-12938-120uL | 120uL | £237.00 |
Quantity:
| E-AB-12938-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
ACO1
Background:
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Synthetic peptide of human ACO1
Purification method:
Affinity purification
Target Synonym:
ACO 1;ACO1;ACOC;Aconitase 1 soluble;Aconitase;Aconitase1;Aconitate hydratase;ACONS;Citrate hydro lyase;Citrate hydro-lyase;Cytoplasmic aconitate hydratase;Ferritin repressor protein;IRE BP 1;IRE-BP 1;IREB 1;IREB1;IREBP;IREBP1;Iron regulatory protein 1;Iron responsive element binding protein 1;Iron-responsive element-binding protein 1;IRP 1;IRP1;OTTHUMP00000045233
UNIProt ID:
P21399