ABL1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-10119-20uL | 20uL | £125.00 |
Quantity:
| E-AB-10119-60uL | 60uL | £172.00 |
Quantity:
| E-AB-10119-120uL | 120uL | £237.00 |
Quantity:
| E-AB-10119-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
-20°C
Further Information
Abbreviation:
ABL1
Background:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant protein of human ABL1
Purification method:
Affinity purification
Target Synonym:
Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine protein kinase 1;Abl 1;ABL;ABL proto oncogene 1 non receptor tyrosine kinase;ABL1;ABL1;bcr/abl;bcr/c abl oncogene protein;c ABL;c abl oncogene 1 non receptor tyrosine kinase;c abl oncogene 1 receptor tyrosine kinase;c ABL1;JTK7;p150;Proto oncogene tyrosine protein kinase ABL1;Proto-oncogene c-Abl;Tyrosine-protein kinase ABL1;v abl Abelson murine leukemia viral oncogene homolog 1;v abl
UNIProt ID:
P00519