ABCC2 Polyclonal Antibody

ABCC2

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.6 mg/mL

Unconjugated

IHC 1:30-150, ELISA 1:2000-10000

Synthetic peptide of human ABCC2

Affinity purification

ABC30;abcC2;ATP binding cassette sub family C (CFTR/MRP) member 2;ATP binding cassette subfamily C member 2;ATP-binding cassette sub-family C member 2;Canalicular multidrug resistance protein;Canalicular multispecific organic anion transporter 1;CMOAT;CMOAT1;cMRP;DJS;KIAA1010;MRP 2;MRP2;Multidrug resistance associated protein 2;Multidrug resistance-associated protein 2

Q92887