NF2 / Merlin Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-40642-50uL | 50uL | £160.00 |
Quantity:
| E-AB-40642-100uL | 100uL | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
NF2
Background:
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway,a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH 7.4
Calculated MW:
70 kDa
Concentration:
2.2mg/ml
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000
Immunogen:
Recombinant Human NF2 protein expressed by E.coli.
ObservedMW:
66-70 kDa
Purification method:
Antigen Affinity Purification
Target Synonym:
ACN;BANF;Merlin;Neurofibromin 2;neurofibromin 2 (merlin);NF2;SCH;Schwannomerlin;Schwannomin
UNIProt ID:
P35240