HTRA1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-40659-50uL | 50uL | £160.00 |
Quantity:
| E-AB-40659-100uL | 100uL | £230.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HTRA1
Background:
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
Calculated MW:
51 kDa
Concentration:
1.5mg/mL
Conjugation:
Unconjugated
Dilution:
WB:1:250-1:500
Immunogen:
Recombinant Human HTRA1 protein expressed by E.coli
ObservedMW:
51 kDa
Purification method:
Antigen Affinity Purification
Target Synonym:
Serine protease HTRA1; High-temperature requirement A serine peptidase 1; L56; Serine protease 11; PRSS11
UNIProt ID:
Q92743