ALIX / PDCD6IP Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-68349-60uL | 60uL | £210.00 |
Quantity:
| E-AB-68349-120uL | 120uL | £291.00 |
Quantity:
| E-AB-68349-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ALIX / PDCD6IP
Background:
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
30kDa/96kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:2000,IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human ALIX / PDCD6IP
ObservedMW:
105kDa
Purification method:
Affinity purification
Target Synonym:
PDCD6IP;AIP1;ALIX;DRIP4;HP95
UNIProt ID:
Q8WUM4