DNA topoisomerase II alpha Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-90025-60uL | 60uL | £210.00 |
Quantity:
| E-AB-90025-120uL | 120uL | £291.00 |
Quantity:
| E-AB-90025-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Immunofluorescence (IF)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
DNA topoisomerase II alpha
Background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
174kDa/177kDa/178kDa/182kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IF 1:20-1:50
Immunogen:
Recombinant fusion protein of human II alpha
ObservedMW:
Refer to figures
Purification method:
Affinity purification
Target Synonym:
TOP2A;TOP2;TP2A
UNIProt ID:
P11388