RBL2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-90642-60uL | 60uL | £210.00 |
Quantity:
| E-AB-90642-120uL | 120uL | £291.00 |
Quantity:
| E-AB-90642-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunofluorescence (IF)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
RBL2
Background:
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
59kDa/128kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:200
Immunogen:
A synthetic peptide of human RBL2
ObservedMW:
130KDa
Purification method:
Affinity purification
Target Synonym:
RBL2;P130;Rb2
UNIProt ID:
Q08999