CDK12 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-90992-60uL | 60uL | £210.00 |
Quantity:
| E-AB-90992-120uL | 120uL | £291.00 |
Quantity:
| E-AB-90992-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
CDK12
Background:
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
141kDa/163kDa/164kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human CDK12
ObservedMW:
205KDa
Purification method:
Affinity purification
Target Synonym:
CDK12;CRK7;CRKR;CRKRS
UNIProt ID:
Q9NYV4