SCAF8 Polyclonal Antibody

Contact us
Elabscience
Product Code: E-AB-92158
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-92158-60uL60uL£210.00
Quantity:
E-AB-92158-120uL120uL£291.00
Quantity:
E-AB-92158-200uL200uL£431.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.

Images

1 / 2
Western blot analysis of extracts of various cell lines using SCAF8 Polyclonal Antibody at 1:1000 dilution.
2 / 2
Western blot analysis of extracts of HeLa cells using SCAF8 Polyclonal Antibody at 1:1000 dilution.
❮❯

Western blot analysis of extracts of various cell lines using SCAF8 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of HeLa cells using SCAF8 Polyclonal Antibody at 1:1000 dilution.

Documents

Further Information

Abbreviation:
SCAF8
Background:
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit (POLR2A, and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
140kDa/147kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000
Immunogen:
Recombinant fusion protein of human SCAF8
ObservedMW:
170KDa
Purification method:
Affinity purification
Target Synonym:
SCAF8;RBM16
UNIProt ID:
Q9UPN6