PRDM9 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-92225-60uL | 60uL | £210.00 |
Quantity:
| E-AB-92225-120uL | 120uL | £291.00 |
Quantity:
| E-AB-92225-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
PRDM9
Background:
The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
103kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human PRDM9
ObservedMW:
103KDa
Purification method:
Affinity purification
Target Synonym:
PFM6; KMT8B; MSBP3; ZNF899; MEISETZ
UNIProt ID:
Q9NQV7