(KD Validated) Smad4 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-92374-60uL | 60uL | £224.00 |
Quantity:
| E-AB-92374-120uL | 120uL | £317.00 |
Quantity:
| E-AB-92374-200uL | 200uL | £465.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
Smad4
Background:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
60kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human Smad4
ObservedMW:
70KDa
Purification method:
Affinity purification
Target Synonym:
SMAD4; DPC4; JIP; MADH4; MYHRS; SMAD family member 4
UNIProt ID:
Q13485