STIM1 Polyclonal Antibody

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Elabscience
Product Code: E-AB-92403
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-92403-60uL60uL£210.00
Quantity:
E-AB-92403-120uL120uL£291.00
Quantity:
E-AB-92403-200uL200uL£431.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded mouse brain using STIM1 Polyclonal Antibody atdilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
2 / 2
Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug STIM1 Polyclonal Antibody.Western blot was performed from the immunoprecipitate using STIM1 Polyclonal Antibody at a dilution of 1:1000.
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Immunohistochemistry of paraffin-embedded mouse brain using STIM1 Polyclonal Antibody atdilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug STIM1 Polyclonal Antibody.Western blot was performed from the immunoprecipitate using STIM1 Polyclonal Antibody at a dilution of 1:1000.

Documents

Further Information

Abbreviation:
STIM1
Background:
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
62kDa/77kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:100,IP 1:50-1:200
Immunogen:
Recombinant fusion protein of human STIM1
ObservedMW:
Refer to figures
Purification method:
Affinity purification
Target Synonym:
STIM1; D11S4896E; GOK; IMD10; STRMK; TAM; TAM1; stromal interaction molecule 1
UNIProt ID:
Q13586