POLA2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-92532-60uL | 60uL | £210.00 |
Quantity:
| E-AB-92532-120uL | 120uL | £291.00 |
Quantity:
| E-AB-92532-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
POLA2
Background:
Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2 is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
40kDa/65kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:3000
Immunogen:
Recombinant fusion protein of human POLA2
ObservedMW:
70kDa
Purification method:
Affinity purification
Target Synonym:
POLA2
UNIProt ID:
Q14181