GPR109A/HM74A/HCAR2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-93136-60uL | 60uL | £210.00 |
Quantity:
| E-AB-93136-120uL | 120uL | £291.00 |
Quantity:
| E-AB-93136-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
GPR109A/HM74A/HCAR2
Background:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
42kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IHC 1:50-1:200
Immunogen:
A synthetic peptide of human GPR109A/HM74A/HCAR2
ObservedMW:
44KDa
Purification method:
Affinity purification
Target Synonym:
HCAR2;GPR109A;HCA2;HM74a;HM74b;NIACR1;PUMAG;Puma-g
UNIProt ID:
Q8TDS4