LDL Receptor Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-93345-60uL | 60uL | £210.00 |
Quantity:
| E-AB-93345-120uL | 120uL | £291.00 |
Quantity:
| E-AB-93345-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.
Further Information
Abbreviation:
LDL Receptor
Background:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
75kDa/76kDa/82kDa/90kDa/95kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200,IF 1:50-1:200
Immunogen:
A synthetic peptide of human LDL Receptor
ObservedMW:
Refer to figures
Purification method:
Affinity purification
Target Synonym:
LDLR; FH; FHC; LDLCQ2; low-density lipoprotein receptor
UNIProt ID:
P01130