(KO Validated) PTPN1 Polyclonal Antibody

Contact us
Elabscience
Product Code: E-AB-93360
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-93360-60uL60uL£210.00
Quantity:
E-AB-93360-120uL120uL£291.00
Quantity:
E-AB-93360-200uL200uL£431.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze/thaw cycles.

Images

1 / 4
Western blot analysis of HeLa using PTPN1 Polyclonal Antibody at 1:500 dilution.
2 / 4
Western blot analysis of C6 using PTPN1 Polyclonal Antibody at 1:500 dilution.
3 / 4
Western blot analysis of C6 using PTPN1 Polyclonal Antibody at 1:400 dilution.
4 / 4
Western blot analysis of extracts from wild type(WT) and PTPN1 knockout (KO) HeLa(KO) cells using PTPN1 Polyclonal Antibody at 1:400 dilution.
❮❯

Western blot analysis of HeLa using PTPN1 Polyclonal Antibody at 1:500 dilution.
Western blot analysis of C6 using PTPN1 Polyclonal Antibody at 1:500 dilution.
Western blot analysis of C6 using PTPN1 Polyclonal Antibody at 1:400 dilution.
Western blot analysis of extracts from wild type(WT) and PTPN1 knockout (KO) HeLa(KO) cells using PTPN1 Polyclonal Antibody at 1:400 dilution.

Documents

Further Information

Abbreviation:
PTPN1
Background:
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
49kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human PTPN1
ObservedMW:
50KDa
Purification method:
Affinity purification
Target Synonym:
PTPN1;PTP1B
UNIProt ID:
P18031