Recombinant Human MKK6 Protein (207 Ser/Asp, 211 Thr/Asp, His & GST Tag)(Active)
| Code | Size | Price |
|---|
| PKSH030414-50ug | 50ug | £652.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Further Information
Abbreviation:
MKK6
Accession:
P52564-1
Activity:
The specific activity was determined to be 1250 nmol/min/mg using inactive MAPK14 as substrate.
Background:
Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the protein kinase superfamily; STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one-protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors; cytokines; ultraviolet light; and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle; heart; and in lesser extent in liver or pancreas.
Calculated MW:
65.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
Baculovirus-Insect Cells
Formulation:
Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His & GST
ObservedMW:
60 kDa
Purity:
> 88 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp
Target Synonym:
MAPKK6;MEK6;MKK6;PRKMK6;SAPKK-3;SAPKK3;MAP2K6
UNIProt ID:
P52564