Elabscience

Recombinant Human UBE2A Protein (His Tag)

Product Code:
 
PKSH030787
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSH030787-100ug100ug£615.00
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Further Information

Abbreviation:
UBE2A
Accession:
P49459
Background:
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A); encoded by human DNA repair genes HHR6A; belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene; a member of the family of ubiquitin-conjugating enzymes. In vivo; HHR6A phosphorylation peaks during the G2/M phase of cell cycle transition; with a concomitant increase in histone H2B ubiquitylation. Mutation of Ser120 to threonine or alanine abolished UBE2A activity; while mutation to aspartate to mimic phosphorylated serine increased UBE2A activity 3-fold. A mutation of UBE2A is consisdered as the cause of a novel X-linked mental retardation (XLMR) syndrome that affects three males in a two-generation family.
Calculated MW:
19.2 kDa
Expression Host:
E.coli
Formulation:
Lyophilized from sterile PBS, 20% glycerol, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His
ObservedMW:
18.5 kDa
Purity:
> 80 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Cys 152
Target Synonym:
Ubiquitin-Conjugating Enzyme E2 A;RAD6 Homolog A;HR6A;hHR6A;Ubiquitin Carrier Protein A;Ubiquitin-Protein Ligase A;UBE2A;RAD6A
UNIProt ID:
P49459

Documents