Recombinant Human GPNMB Protein (aa 1-474, His Tag)
| Code | Size | Price |
|---|
| PKSH031159-100ug | 100ug | £664.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
GPNMB
Accession:
Q14956-2
Background:
GPNMB belongs to the PMEL / NMB family; also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ); is a transmembrane glycoprotein that is expressed in numerous cells; including osteoclasts; macrophages; dendritic cells; and tumor cells. It is suggested to influence osteoblast maturation; cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization; and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
Calculated MW:
52.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
Purity:
> 98 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Pro 474
Target Synonym:
Transmembrane Glycoprotein NMB;Transmembrane Glycoprotein HGFIN;GPNMB;HGFIN;NMB;Osteoactivin
UNIProt ID:
Q14956