Recombinant Human PIGR Protein (365 Ser/Gly, His Tag)(Active)
| Code | Size | Price |
|---|
| PKSH031844-100ug | 100ug | £664.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
PIGR
Accession:
NP_002635.2
Activity:
Immobilized rhhuman IgM at 2 ug/ml (100 ul/well) can bind biotinylated PIGR with a linear range of 0.94-15 ng/ml. 2. When human human IgM is immobilized at 2 ug/ml (100 ul/well), PIGR inhibits 50% binding of biotinylated PIGR (0.062 ug/ml) at the concentration range of 0.03-20 ug/ml.
Background:
Polymeric immunoglobulin receptor, also known asPIGR, is a member of the immunoglobulin superfamilyand aFc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion ofIgAandIgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.
Calculated MW:
69 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
Purity:
> 97 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Arg 638, 365 Ser/Gly
Target Synonym:
Polymeric Immunoglobulin Receptor;PIgR;Poly-Ig Receptor;Hepatocellular Carcinoma-Associated Protein TB6;PIGR