PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody[L291H4]
| Code | Size | Price |
|---|
| E-AB-F1366J-20Tests | 20Tests | £151.00 |
Quantity:
| E-AB-F1366J-100Tests | 100Tests | £277.00 |
Quantity:
| E-AB-F1366J-100Testsx2 | 100Testsx2 | £510.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1, κ
Antibody Clonality: Monoclonal
Antibody Clone: L291H4
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
Ice packs
Storage:
This product can be stored at 2-8°C for 12 months. Do not freeze.
![Human peripheral blood lymphocytes are stained with FITC Anti-Human CD3 Antibody and PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody[L291H4] (Left). Lymphocytes are stained with FITC Anti-Human CD3 Antibody and PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control (Right).](/images/blue_dot.png)
Further Information
Abbreviation:
CD194/CCR4
Background:
CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4-Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+ T cells leads to Th1-type polarization of CD4+ T cells and augmentation of CD8+T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:
5 uL/Test
Conjugation:
PerCP/Cyanine5.5
Target Synonym:
CKR4;K5-5;CMKBR4;ChemR13;CC-CKR-4;MGC88293;HGCN:14099;
UNIProt ID:
P51679
Usage:
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.