Langerin Antibody / CD207
| Code | Size | Price |
|---|
| NSJ-V8856SAF-100UG | 100ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1 kappa
Antibody Clonality: Recombinant Antibody
Antibody Clone: rLGRN/1821
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
Aliquot the recombinant Langerin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details:
ELISA: 2-4ug/ml (order BSA-free format for coating)
Application Note:
Optimal dilution of the recombinant Langerin antibody should be determined by the researcher.
Description:
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
A portion of amino acids 74-213 was used as the immunogen for the recombinant Langerin antibody.
Limitation:
This recombinant Langerin antibody is available for research use only.
Localization:
Cell surface and cytoplasmic
Purity:
Protein A/G affinity
Uniprot #:
Q9UJ71