Cytokeratin 17 Antibody

Immunohistochemistry (FFPE): 1-2ug/ml

Optimal dilution of the Keratin 17 antibody should be determined by the researcher.

Cytokeratin 17 (CK17) is normally expressed in the basal cells ofcomplex epithelia but not in stratified orsimple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glandssuch as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Recombinant full-length human KRT17 protein was used as the immunogen for the Keratin 17 antibody.

This Keratin 17 antibody is available for research use only.

Cytoplasm

Protein A/G affinity

Q04695