SHP2 Antibody
| Code | Size | Price |
|---|
| NSJ-F53772-0.4ML | 0.4 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Aliquot the SHP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details:
Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
Application Note:
Titration of the SHP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Format:
Antigen affinity purified
Formulation:
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 526-551 from the human protein was used as the immunogen for this SHP2 antibody.
Limitation:
This SHP2 antibody is available for research use only.
Purity:
Antigen affinity
Uniprot #:
Q06124