CD40 Antibody

Immunofluorescence: 1-2ug/ml,Flow cytometry: 0.5-1ug/million cells

Optimal dilution of the CD40 antibody should be determined by the researcher.

This antibody is specific for the soluble form of CD40. It is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

C-terminal region amino acids RDPVCHPLGA were used as the immunogen for the CD40 antibody.

This CD40 antibody is available for research use only.

Cell surface and cytoplasmic

Protein G affinity chromatography

P25942