FOXP3 Antibody / Scurfin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Optimal dilution of the antibody should be determined by the researcher.

Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Full-length His-tagged mouse FOXP3 protein was used as the immunogen for this FOXP3 antibody.

This FOXP3 antibody is available for research use only.

Predominantly nuclear, some cytoplasmic

Protein G affinity chromatography

Q9BZS1