Estrogen Receptor alpha Antibody
| Code | Size | Price |
|---|
| NSJ-V7060SAF-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1 kappa
Antibody Clonality: Monoclonal
Antibody Clone: NR3Ga-1
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store the Estrogen Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Documents
Further Information
Application Details:
Western blot: 1-2ug/ml
Application Note:
Titration of the Estrogen Receptor antibody may be required for optimal performance.
Description:
Estrogen receptor (ER) is an important regulator of growth and differentiation in the mammary gland. It is found in two forms, alpha and beta. Both forms are widely expressed, however, alpha is the predominant form in endometrium and breast cancer cells, and beta is more highly expressed in brain, kidney, heart, lung and bone. Activated Estrogen receptor dimerizes and forms both homo- and heterodimers. ER contains five domains: A-F. The A and B domain are able to weakly activate ER in the absence of ligand. The C domain binds DNA and the E domain contains the ligand binding site. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. This antibody is specific to estrogen receptor alpha and shows minimal cross-reaction with other members of the family.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Gene ID #:
2099
Immunogen:
Estrogen Receptor alpha protein (aa 2-185) was used as the immunogen for this antibody.
Limitation:
This Estrogen Receptor antibody is available for research use only.
Localization:
Nuclear
Purity:
Protein G affinity chromatography