Langerin Antibody / CD207

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NSJ Bioreagents
Product Code: NSJ-V7993SAF
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V7993SAF-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2a kappa
Antibody Clonality: Monoclonal
Antibody Clone: LGRN/1821
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
Store the Langerin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Images

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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Langerin antibody (clone LGRN/1821). These results demonstrate the foremost specificity of the LGRN/1821 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Langerin antibody (clone LGRN/1821). These results demonstrate the foremost specificity of the LGRN/1821 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a

Documents

Further Information

Application Details:
ELISA (order BSA-free format for coating),Western blot: 1-2ug/ml
Application Note:
Optimal dilution of the antibody should be determined by the researcher.
Description:
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
A recombinant human partial protein (amino acids 74-213) was used as the immunogen for the Langerin antibody.
Limitation:
This Langerin antibody is available for research use only.
Localization:
Cell surface, cytoplasmic
Purity:
Protein G affinity chromatography
Uniprot #:
Q9UJ71