Kallikrein 5 Antibody / KLK5

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NSJ Bioreagents
Product Code: NSJ-V8499SAF
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V8499SAF-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2a kappa
Antibody Clonality: Monoclonal
Antibody Clone: KLK5/3845
Regulatory Status: RUO
Target Species: Human
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
Store the Kallikrein 5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Images

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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using KLK5 antibody (clone KLK5/3845). These results demonstrate the foremost specificity of the KLK5/3845 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a flu
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using KLK5 antibody (clone KLK5/3845). These results demonstrate the foremost specificity of the KLK5/3845 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a flu

Documents

Further Information

Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Application Note:
Optimal dilution of the Kallikrein 5 antibody should be determined by the researcher.
Description:
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
A portion of amino acids 36-177 from the human protein was used as the immunogen for the Kallikrein 5 antibody.
Limitation:
This Kallikrein 5 antibody is available for research use only.
Localization:
Secreted
Purity:
Protein G affinity chromatography
Uniprot #:
Q9Y337