GITR Antibody / TNFRSF18
| Code | Size | Price |
|---|
| NSJ-V3050SAF-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b lambda
Antibody Clonality: Monoclonal
Antibody Clone: DTA-1
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
Storage:
Store the GITR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Documents
Further Information
Application Details:
Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 0.5-1ug/ml
Application Note:
Optimal dilution of the GITR antibody should be determined by the researcher.
Description:
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.
Limitation:
This GITR antibody is available for research use only.
Localization:
Secreted, cell surface
Purity:
Protein G affinity chromatography
Uniprot #:
O35714 (Mouse)