Cyclin D1 Antibody / CCND1

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NSJ Bioreagents
Product Code: NSJ-V8053SAF
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V8053SAF-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2b kappa
Antibody Clonality: Monoclonal
Antibody Clone: CCND1/3548
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
Store the Cyclin D1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Images

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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Cyclin D1 antibody (clone CCND1/3548). These results demonstrate the foremost specificity of the CCND1/3548 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination wit
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Cyclin D1 antibody (clone CCND1/3548). These results demonstrate the foremost specificity of the CCND1/3548 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination wit

Documents

Further Information

Application Details:
ELISA (order BSA-free format for coating)
Application Note:
Optimal dilution of the antibody should be determined by the researcher.
Description:
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
A recombinant human partial protein (amino acids 115-270) was used as the immunogen for this Cyclin D1 antibody.
Limitation:
This Cyclin D1 antibody is available for research use only.
Purity:
Protein G affinity chromatography
Uniprot #:
P24385