BAP1 Antibody / BRCA1-Associated Protein 1

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NSJ Bioreagents
Product Code: NSJ-V7371SAF
Product Group: Primary Antibodies
Supplier: NSJ Bioreagents
CodeSizePrice
NSJ-V7371SAF-100UG100 ug£534.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: Mouse IgG2c kappa
Antibody Clonality: Monoclonal
Antibody Clone: BAP1/2432
Regulatory Status: RUO
Target Species: Human
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
Store the BAP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Images

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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using BAP1 antibody (clone BAP1/2432). These results demonstrate the foremost specificity of the BAP1/2432 mAb.<BR>Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using BAP1 antibody (clone BAP1/2432). These results demonstrate the foremost specificity of the BAP1/2432 mAb.<BR>Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a

Documents

Further Information

Application Details:
ELISA (order BSA/sodium azide-free format for coating)
Application Note:
Optimal dilution of the BAP1 antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Description:
The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
A portion of amino acids 191-326 from the human protein was used as the immunogen for the BAP1 antibody.
Limitation:
This BAP1 antibody is available for research use only.
Localization:
Nuclear, cytoplasmic
Purity:
Protein G affinity chromatography
Uniprot #:
Q92560