Beta Arrestin 1 Antibody
| Code | Size | Price |
|---|
| NSJ-F54014-0.1ML | 0.1 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 6A1-D7-C9
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store the Beta Arrestin 1 antibody at -20oC.
Documents
Further Information
Application Details:
Western blot: 1:500
Application Note:
The stated application concentrations are suggested starting points. Titration of the Beta Arrestin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. [UniProt]
Format:
Purified
Formulation:
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Immunogen:
A human recombinant protein was used as the immunogen for this Beta Arrestin 1 antibody.
Limitation:
This Beta Arrestin 1 antibody is available for research use only.
Purity:
Protein G affinity
Uniprot #:
P49407