DDR2 Antibody

Western blot: 1:100-1:1600

Titration of the DDR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq].

Ascites

In ascites with 0.09% sodium azide

A portion of amino acids 290-320 from the human protein was used as the immunogen for this DDR2 antibody.

This DDR2 antibody is available for research use only.

Ascites

Q16832