PINK1 Antibody
| Code | Size | Price |
|---|
| NSJ-F53741-0.1ML | 0.1 ml | £502.00 |
Quantity:
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Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 38CT20.8.5
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Aliquot the PINK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Application Details:
Western blot: 1:500-1:2000,IHC (Paraffin): 1:10-1:50
Application Note:
Titration of the PINK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
PINK1 protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form. [UniProt]
Format:
Ascites
Formulation:
In ascites with 0.09% sodium azide
Immunogen:
Recombinant protein was used to produced this PINK1 antibody.
Limitation:
This PINK1 antibody is available for research use only.
Purity:
Ascites
Uniprot #:
Q9BXM7