TGFB1/2/3 Antibody / TGF Beta 1/2/3
| Code | Size | Price |
|---|
| NSJ-V2889SAF-100UG | 100 ug | £534.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1 kappa
Antibody Clonality: Monoclonal
Antibody Clone: 1D11.16.8
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Functional Study
- Immunofluorescence (IF)
- Neutralisation
- Western Blot (WB)
Storage:
Store the TGF-beta antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Documents
Further Information
Application Details:
Cytokine neutralization (order BSA/sodium azide-free format),Functional assay (order BSA/sodium azide-free format),ELISA: 0.1-0.4ug/ml (detect); 2-8ug/ml (capture),Immunofluorescence: 8-25ug/ml,Western blot: 1-2ug/ml
Application Note:
Optimal dilution of the TGF-beta antibody should be determined by the researcher.
Description:
This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.
Limitation:
This TGF-beta antibody is available for research use only.
Purity:
Protein G affinity chromatography
Uniprot #:
P01137, P10600, P61812