Pyruvate Kinase Antibody / PKM2
| Code | Size | Price |
|---|
| NSJ-F54017-0.1ML | 0.1 ml | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: Mouse IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 1A7-G6-H6
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Non-Human Primates
- Rat
Applications:
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Store the PKM2 antibody at -20oC.
Documents
Further Information
Application Details:
Western blot: 1:1000,ICC/Immunofluorescence: 1:400
Application Note:
The stated application concentrations are suggested starting points. Titration of the PKM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]
Format:
Purified
Formulation:
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Immunogen:
A human recombinant partial protein was used as the immunogen for this PKM2 antibody.
Limitation:
This PKM2 antibody is available for research use only.
Purity:
Protein G affinity
Uniprot #:
P14618