Mouse Anti-Human CD130 BioActive Antibody, Clone B-S12, Azide free

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Diaclone
Product Code: 852.110.000
Product Group: Primary Antibodies
Supplier: Diaclone
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852.110.000200ug/200ul£232.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-S12
Regulatory Status: RUO
Target Species: Human
Application: Functional Study

Further Information

Activity:
Activates cells carrying gp130. Induces gp130 activation Jak 1 Jak 2 Stat 1 and Stat 3 phosphorylation
Antigen:
CD130 / gp130
Antigen Synonyms:
gp130
Biological Acivity:
Activates cells carrying gp130. Induces gp130 activation Jak 1 Jak 2 Stat 1 and Stat 3 phosphorylation
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Natural soluble gp130
Reactivity:
Human
Research Area:
Cytokine / Chemokine ReceptorsCD Markers
Specificity:
Recognises the Gp130 common subunit for IL-6 IL-11 OSM LIF CNTF CT-1 receptors a 130-140 kDa protein
Workshop:
VI

References

  1. Althoff K. et al.Biochem J.2001;353(Pt 3): 663-72.. Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.. https://www.ncbi.nlm.nih.gov/pubmed/11171064
  2. Ancey C. et al. Cardiovasc Res.2003; 59(1): 78-85.. Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation.. https://www.ncbi.nlm.nih.gov/pubmed/12829178
  3. Ancey C. et al. Cytokine2002; 18(4): 199-205.. Secretion of IL-6 IL-11 and LIF by human cardiomyocytes in primary culture. https://www.ncbi.nlm.nih.gov/pubmed/12126642
  4. Autissier P. et al. Int Immunol.1998; 10(12): 1881-9.. Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb. https://www.ncbi.nlm.nih.gov/pubmed/9885909
  5. Fourcin M. et al. J Biol Chem.1996; 271(20): 11756-60.. gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses. https://www.ncbi.nlm.nih.gov/pubmed/8662709
  6. Giese B. et al. J. Biol. Chem. 2003; 278(40): 39205 - 39213. Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis. https://www.ncbi.nlm.nih.gov/pubmed/12878601
  7. Gu Z. J. et al. Leukemia2000; 14(1): 188-97.. Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors. https://www.ncbi.nlm.nih.gov/pubmed/10637495
  8. Hammacher A. et al. Biochem2000; J 345 Pt 1: 25-32.. Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors. https://www.ncbi.nlm.nih.gov/pubmed/10600635
  9. Hammacher A. et al. J Biol Chem.1998; 273(35): 22701-7.. The immunoglobulin-like module of gp130 is required for signaling by interleukin-6 but not by leukemia inhibitory factor. https://www.ncbi.nlm.nih.gov/pubmed/9712900
  10. Horsten U. et al. J Biol Chem.1997; 272(38): 23748-57.. Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex. https://www.ncbi.nlm.nih.gov/pubmed/9295319
  11. Jover R. et al. Faseb J.2002; 16(13): 1799-801.. Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved.. https://www.ncbi.nlm.nih.gov/pubmed/12354697
  12. Kallen K. J. et al. J Biol Chem.1999; 274(17): 11859-67.. Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. https://www.ncbi.nlm.nih.gov/pubmed/10207005
  13. Kube D. et al. Blood 2001; 98(3): 762 - 770. STAT3 is constitutively activated in Hodgkin cell lines. https://www.ncbi.nlm.nih.gov/pubmed/11468177
  14. Kurth I. et al. J Immunol.1999; 162(3): 1480-7.. Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes. https://www.ncbi.nlm.nih.gov/pubmed/9973404
  15. Kurth I. et al. J Immunol.2000; 164(1): 273-82.. Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.. https://www.ncbi.nlm.nih.gov/pubmed/10605021