Mouse Anti-Human CD126 BioActive Antibody, Clone B-R6, Azide free

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Diaclone
Product Code: 852.030.000
Product Group: Primary Antibodies
Supplier: Diaclone
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852.030.000200ug/200ul£232.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-R6
Regulatory Status: RUO
Target Species: Human
Application: Functional Study

Further Information

Activity:
Inhibits IL-6 induced proliferation of XG-1 cells
Antigen:
CD126 / IL-6R
Antigen Synonyms:
IL-6R / gp80
Biological Acivity:
Inhibits IL-6 induced proliferation of XG-1 cells
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
gp80 transfected CHO cell line
Reactivity:
Human
Research Area:
Cytokine / Chemokine ReceptorsCD Markers
Specificity:
Recognises the Interleukin-6 Ra subunit IL-6 Ra IL-6 R a 80 kDa protein
Workshop:
V - VI

References

  1. Burger R. et al. The Haematology Journal 2001; 2(1): 42-53. Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. https://www.ncbi.nlm.nih.gov/pubmed/11920233
  2. Burger R. et al.Haematologica 2017;102(2) :381-390. Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth. https://www.ncbi.nlm.nih.gov/pubmed/27658435
  3. Clement C. et al CR.3.2 Leucocyte Typing V Boston 1993. .
  4. Dubois B. et al. J. Immunol. 1998; 161(5): 2223 -2231. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. https://www.ncbi.nlm.nih.gov/pubmed/9725215
  5. Dubois B. et al. J. Immunol. 1999; 162(6): 3428 -3436. Toward a role of dendritic cells in the germinal center reaction: triggering of B cell proliferation and isotype switching. https://www.ncbi.nlm.nih.gov/pubmed/10092798
  6. Gougelet A. et al.PLoS One2009;4(11):e8026. Lymphoma and myeloma cell resistance to cytotoxic agents and ionizing radiations is not affected by exposure to anti-IL-6 antibody.. https://www.ncbi.nlm.nih.gov/pubmed/19956602
  7. Gu Z. J. et al. Leukemia2000; 14(1): 188-97.. Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors. https://www.ncbi.nlm.nih.gov/pubmed/10637495
  8. Menetrier-Caux C. et al. Blood 1998; 92(12) : 4778 - 4791. Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. https://www.ncbi.nlm.nih.gov/pubmed/9845545
  9. Muller-Newen G. et al. Eur J Biochem.1996; 236(3): 837-42.. Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. https://www.ncbi.nlm.nih.gov/pubmed/8665902