Mouse Anti-Human CD261 Monoclonal Antibody, Clone B-N28, Azide free

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Diaclone
Product Code: 852.980.000
Product Group: Primary Antibodies
Supplier: Diaclone
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852.980.000200ug/200ul£232.00
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Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: B-N28
Regulatory Status: RUO
Target Species: Human

Further Information

Antigen:
TRAIL R1 / DR4
Antigen Synonyms:
DR4 TRAIL R1
Conjugate:
Azide free
Format:
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Recombinant human TRAIL R1/Fc chimera
Reactivity:
Human
Research Area:
ApoptosisCD Markers
Specificity:
Recognises a 43-46 kDa protein
Workshop:
VIII

References

  1. Chen S. et al. Mol Cancer2010?; 9: 23. Dissecting the roles of DR4 DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.. https://www.ncbi.nlm.nih.gov/pubmed/20113484
  2. Chen S. et al. Mol. Pharmacol.2007; 72(5): 1269-1279.. CCAAT/Enhancer Binding Protein Homologous Protein-Dependent Death Receptor 5 Induction and Ubiquitin / Proteasome-Mediated Cellular FLICE-Inhibitory Protein Down-Regulation Contribute to Enhancement of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Dimethyl-Celecoxib in Human Non Small-Cell Lung Cancer Cells. https://www.ncbi.nlm.nih.gov/pubmed/17684158
  3. Dhandapani L. et al.Cancer Res. 2011; 71: 5245 - 5254. Retinoic Acid Enhances TRAIL-Induced Apoptosis in Cancer Cells by Upregulating TRAIL Receptor 1 Expression. https://www.ncbi.nlm.nih.gov/pubmed/21685476
  4. Dufour F. et al. Cell Death Differ.2017; 24(3): 500-510. N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death. https://www.ncbi.nlm.nih.gov/pubmed/28186505
  5. Fan S. et al. Neoplasia2010; 12(4): 346-56. The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. https://www.ncbi.nlm.nih.gov/pubmed/20360945
  6. Fu L. et al.Mol Cancer2010; 9: 31. c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.. https://www.ncbi.nlm.nih.gov/pubmed/21172010
  7. Han B. et al.Oncotarget2015;6(19): 17532-42. The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5.. https://www.ncbi.nlm.nih.gov/pubmed/26009898
  8. Iurlaro R. et al.Mol Cell Biol. 2017 May 2;37(10). pii: e00479-16.. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors.. https://www.ncbi.nlm.nih.gov/pubmed/28242652
  9. Kauh J. et al. PLoS One2010;5(4): e10376. c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.. https://www.ncbi.nlm.nih.gov/pubmed/20442774
  10. Li B. et al. Cancer Prevention Research 2012; 5: 612 - 620. The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition. https://www.ncbi.nlm.nih.gov/pubmed/22345097
  11. Lin Y.-D. et al. Cancer Res.2008; 68(13): 5335-5344.. CAAT/Enhancer Binding Protein Homologous Protein-Dependent Death Receptor 5 Induction Is a Major Component of SHetA2-Induced Apoptosis in Lung Cancer Cells.. https://www.ncbi.nlm.nih.gov/pubmed/18593935
  12. Oh Y. T. et al. Oncotarget2015; 6(38): 41324-38. Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.. https://www.ncbi.nlm.nih.gov/pubmed/26510914
  13. Qi L. et al.Apoptosis2011; 16(11): 1150-64. Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis.. https://www.ncbi.nlm.nih.gov/pubmed/21877214
  14. Raja S. M. et al. Mol. Cancer Ther.2008; 7(7): 2212-2223.. The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.. https://www.ncbi.nlm.nih.gov/pubmed/18645030
  15. Vermot-Desroches C. et al. Cell Immunol. 2005;236(1-2):86-91. Characterization of monoclonal antibodies directed against trail or trail receptors. https://www.ncbi.nlm.nih.gov/pubmed/16157319